| 货号 | 3857S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:50) |
| 供应商 | CST |
| 背景 | Arrestin proteins function as negative regulators of G protein coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling (1). Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (or X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as β-arrestin 1) and arrestin 3 (or β-arrestin 2) are ubiquitously expressed and bind to most GPCRs (2). β-arrestin proteins function as adapters and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in ERK activation pathways (3,4). β-arrestins are also involved in some receptor tyrosine kinase signaling pathways (5-8). Additional evidence suggests that β-arrestin proteins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors (9,10). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
Immunohistochemical analysis of paraffin-embedded human melanoma using β-Arrestin 2 (C16D9) Rabbit mAb.免疫组织化学方法检测石蜡包埋的人黑色素瘤组织，使用的抗体是-Arrestin 2 (C16D9) Rabbit mAb。 | |
Western blot analysis of extracts from various cell lines using β-Arrestin 2 (C16D9) Rabbit mAb.western blot方法检测细胞提取物：各种细胞系，使用的抗体是β-Arrestin 2 (C16D9) Rabbit mAb。 |
