| 货号 | 12467S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb recognizes the Aβ-37 isoform of the β-amyloid peptides. This antibody does not cross-react with other β-amyloid peptides. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain, which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimers disease (AD) (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell-cycle dependent and peaks during G2/M phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 4 |
Western blot analysis of human Aβ-37, Aβ-38, Aβ-39, Aβ-40, Aβ-42, and Aβ-43 peptides (10 ng) using β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb (upper) or β-Amyloid (D54D2) XP® Rabbit mAb #8243 (lower). Western blot检测人 Aβ-37，Aβ-38，Aβ-39，Aβ-40，Aβ-42和Aβ-43 肽段(10 ng)，使用的抗体为 β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb兔单抗（上图）或β-Amyloid (D54D2) XP® Rabbit mAb #8243兔单抗（下图）。 | |
Western blot analysis of the indicated amounts of human Aβ-37 peptide using β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb. Western blot 定量检测人Aβ-37 肽段，使用的抗体为 β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb兔单抗。 | |
Western blot analysis of brain extracts from 13-month old wild-type and TG2576 mice using β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). Western blot检测13个月龄野生型及TG2576小鼠的大脑，使用的抗体为 β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb 兔单抗（上图）或 β-Actin (D6A8) Rabbit mAb #8457 兔单抗（下图）。 |
