β2-Adrenergic Receptor (D6H2) Rabbit mAb
货号：
8513S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8513S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | β2-Adrenergic Receptor (D6H2) Rabbit mAb recognizes endogenous levels of total β2-adrenergic receptor protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | There are four major Adrenergic Receptor (AR) subtypes (α1, α2, β1, β2). Each of the subtypes has been classified by their unique responses to agonists and antagonists. Adrenergic receptors belong to the family of guanine nucleotide-binding, regulatory protein-coupled receptors (GPCR) which transverse the plasma membrane seven times. The transmembrane regions are hydrophobic and are interconnected by hydrophilic loops (1). β2-Adrenergic Receptor (β2AR) is the most studied receptor of the catecholamine system. β2AR stimulation occurs through the catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline) acting as neuromodulators in the central nervous system and as hormones in the vascular system. β2AR activation results in coupling to heterotrimeric G proteins and activation of the second messengers cAMP and phosphatidylinositol, ultimately leading to changes in cellular physiology. GPCR kinases (GRKs) terminate β2AR signaling through phosphorylation of the GPCR and by recruiting β-arrestin. β-arrestin binding uncouples the receptor from the G protein, thereby terminating G protein–mediated signaling (desensitization), and initiating clathrin-mediated endocytosis (internalization) of β2AR (2). β-adrenergic blocking agents (beta blockers) are drugs that block catecholamines from binding to βAR and are prescribed for cardiac arrhythmias, cardioprotection after myocardial infarction (heart attack), and hypertension (3). |
| 存放说明 | -20C |
| 计算分子量 | 50-100 |
参考图片Western blot analysis of ACHN cells or 293T cells, either mock transfected (-) or transfected (+) with a cDNA expression construct encoding human β2-adrenergic receptor (hβ2AR), using β2-Adrenergic Receptor (D6H2) Rabbit mAb. Western blot方法检测ACHN细胞和293T细胞，细胞不转染（-）或用cDNA表达构建体编码β2-肾上腺素受体 (hβ2AR)转染（+），使用的抗体为β2-Adrenergic Receptor (D6H2) Rabbit mAb. |
