Zap-70 (L1E5) Mouse mAb
货号：
2709S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2709S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 目标/特异性 | Zap-70 (L1E5) Mouse mAb detects endogenous levels of total Zap-70 protein. It does not cross-react with other related proteins. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement (1). Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck (2-6). Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia (7,8). |
| 存放说明 | -20C |
| 计算分子量 | 70 |
参考图片Western blot analysis of extracts from Jurkat and Ramos cells, as well as 293 cells overexpressing Syk, using Zap70 (L1E5) Mouse mAb. Results show that this antibody does not cross-react with any B cell proteins (lane 2) or Syk (lane 3).Western免疫印迹。用Zap70 (L1E5) Mouse mAb 研究Jurkat 和 Ramos 细胞以及过表达Syk的293细胞的细胞提取液。结果显示此抗体不与B细胞中的任何蛋白交叉反应 (泳道 2) 或Syk (泳道 3)。 |
