| 货号 | 14768S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IF-IC |
| 使用方法 | WB(1:1000) IP (1:100) IF-IC (1:400) |
| 供应商 | CST |
| 背景 | Nucleotide excision repair (NER) is a process by which cells identify and repair DNA lesions resulting from chemical or radiation exposure (1). XPC forms a complex with HR23B (2) that acts as a damage sensor due to its high affinity for geometry distorting DNA lesions. This complex localizes to sites of DNA damage and recruits the remaining members of the preincision complex necessary for initiation of NER (3). XPC is one of eight NER proteins (XPA-G, XPV) where defects result in Xeroderma pigmentosum, a disease characterized by sunlight sensitivity, a predisposition to cancer of exposed tissue, and, in some instances, neurological defects (4). |
| 存放说明 | -20C |
| 计算分子量 | 120 |
Confocal immunofluorescent analysis of MCF7 (left) and MDA-MB-231 (right) cells using (D1M5Y) Rabbit mAb (green) and β-Actin (8H10D10) Mouse mAb #3700 (red). | |
Western blot analysis of extracts from MCF7 and MDA-MB-231 cells using XPC (D1M5Y) Rabbit mAb (upper) and α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower). | |
Immunoprecipitation of XPC from MCF7 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or XPC (D1M5Y) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot was performed using XPC (D1M5Y) Rabbit mAb. |
