XPA (D9U5U) Rabbit mAb
货号：
14607S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 14607S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Nucleotide excision repair (NER) is a process by which cells identify and repair DNA lesions that result from chemical and radiation exposure (1). The DNA binding protein XPA is an essential part of a pre-incision complex that forms at sites of damage, and is necessary for the initiation of nucleotide excision repair (2). XPA is one of eight NER proteins (XPA-G, XPV) encoded by genes that are defective in cases of xeroderma pigmentosum, a disorder characterized by sensitivity to sunlight, predisposition to exposed tissue cancers, and neurological defects in some patients (3). Activation of XPA follows phosphorylation at Ser196 and results in increased NER activity. Phosphorylation of XPA at Ser196 is induced by UV exposure in an ATR-dependant fashion (4) and promotes nuclear accumulation of XPA (5). Research studies suggest that XPA may be a direct substrate of the serine/threonine kinase ATR (4) and that NER activity may be negatively regulated through dephosphorylation of Ser196 by the phosphatase WIP1 (6). |
| 存放说明 | -20C |
| 计算分子量 | 40 |
参考图片Western blot analysis of extracts from 293T and Colo205 cells (high expression), and A549 and SNB19 cells (low expression), using XPA (D9U5U) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). |
