| 货号 | 12691S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | xCT/SLC7A11 (D2M7A) Rabbit mAb recognizes endogenous levels of total xCT/SLC7A11 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | The x(c)(-) cysteine/glutamate antiporter consists of a light chain subunit (xCT/SLC7A11) that confers substrate specificity and a glycosylated heavy chain subunit (4F2hc/SLC3A2) located on the cell surface (1,2). The heterodimeric amino acid transport system x(c)(-) provides selective import of cysteine into cells in exchange for glutamate and regulating intracellular glutathione (GSH) levels, which is essential for cellular protection from oxidative stress (3). Research studies have shown that xCT expression increases in various tumors, including gliomas, and have implicated xCT in GSH-mediated anticancer drug resistance (4,5). Researchers have found that xCT provides neuroprotection by enhancing glutathione export from non-neuronal cells (6). Moreover, investigators identified xCT as the fusion-entry receptor for Kaposis sarcoma-associated herpesvirus (7). |
| 存放说明 | -20C |
| 计算分子量 | 35 |
Western blot analysis of extracts from Huh7 and Hep G2 cells using xCT/SLC7A11 (D2M7A) Rabbit mAb. 使用xCT/SLC7A11 (D2M7A) Rabbit mAb兔单抗对Huh7和Hep G2细胞提取物进行western blot分析。 |
