WTX (D38E5) Rabbit mAb
货号：
5854S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5854S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | WTX (D38E5) Rabbit mAb detects transfected levels of total WTX protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | WTX (Wilms’ tumor gene on the X chromosome) is a developmentally regulated gene with a potentially important role in kidney development (1). Functional studies of WTX suggest that it acts as a tumor suppressor gene in renal cells by promoting β-catenin ubiquitination and degradation, thereby antagonizing WNT/β-catenin signaling (1,2). WTX is found to be inactivated in 30% of Wilms’ tumors, mostly by chromosomal deletion (3). Wilms’ tumor is a pediatric kidney cancer that arises from cells that fail to differentiate during kidney development (4). Inactivation of the WT1 tumor suppressor gene accounts for 10-15% of Wilms’ tumor cases (5). WTX has been shown to enhance WT1-mediated transactivation, suggesting a physiologically significant interaction between WT1 and WTX (6). WTX may be directly involved in the transcriptional regulation of cellular differentiation in the kidney through interactions with WT1 and other transcription factors (6). |
| 存放说明 | -20C |
| 计算分子量 | 200 |
参考图片Western blot analysis of extracts from HeLa cells, untransfected or transfected with a contruct overexpressing human WTX, using WTX (D38E5) Rabbit mAb.未转染或转染了过表达人WTX质粒的HeLa细胞提取物使用WTX (D38E5) 兔单抗进行western blot实验。 |
