WIP1 (D4F7) Rabbit mAb
货号：
11901S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11901S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Wild-type p53 induced phosphatase 1 (WIP1)/protein phosphatase magnesium-dependent 1 delta (ppm1d) is a member of the PP2C family of serine/threonine protein phosphatases. WIP1 was initially identified as a p53 target gene, induced in response to ionizing radiation (1). Studies have shown that WIP1 is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways (reviewed in 2,3). WIP1 functions in returning cells to a homeostatic state following DNA damage (4,5), as well as in maintaining p53-dependent homeostasis under nonstress conditions (6). Researchers have shown that increased expression of WIP1 is associated with poor prognosis and lower survival rate in some human cancers (7,8). In contrast, overexpression of WIP1 in p53-negative tumor cells sensitizes them to chemotherapy-induced apoptosis while protecting normal tissue during treatment (9).使用WIP1 (D4F7) 兔mAb对多种细胞提取物进行western blot。野生型p53诱导磷酸酶1（WIP1）/蛋白磷酸酶镁依赖1delta（ppm1d）是丝氨酸/苏氨酸蛋白磷酸酶家族PP2C的一员。WIP1最初被认为是电离辐射应激后p53的靶基因（1）。研究证明WIP1在人类癌症中过表达并设计到调控多种DNA损伤信号通路（2,3）。WIP1发挥着在DNA损伤后将细胞送回稳定状态的功能（4，5），同时也维持着非压力条件下p53-依赖的稳态（6）。研究人员发现WIP1的过表达与某些人类肿瘤的不良预后和低存活率相关（7,8）。相对的，在p53缺乏的肿瘤细胞中过表达WIP1能够在治疗过程中加强细胞对于化疗诱导的凋亡的敏感性以通过保护正常组织（9）。 |
| 存放说明 | -20C |
| 计算分子量 | 79 |
参考图片Western blot analysis of extracts from various cell lines using WIP1 (D4F7) Rabbit mAb.使用WIP1 (D4F7) Rabbit mAb对多种细胞提取物进行western blot。 |
