VRK1 (1F6) Mouse mAb
货号:
3307S 基本售价:
3360.0 元 规格:
-
产品信息
概述货号 | 3307S |
反应种属 | Human |
来源宿主 | Mouse |
应用 | W |
使用方法 | WB(1:1000) |
性能供应商 | CST |
背景 | The vaccinia-related kinase (VRK) proteins are a new group of Ser/Thr kinases in the human kinome. This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3 (1-3). The VRK1 has autophosphorylation activity and phosphorylates several transcription factors, including p53 (4), ATF2 (5), and c-Jun (6). VRK2 is associated with the endoplasmic reticulum (7). VRK3 suppresses Erk activity through direct interaction and activation of the MAP kinase phosphatase VHR (8). Further functional and structural analysis of VRK proteins will elucidate important new aspects of cell regulation.牛痘相关激酶(VRK)是人类蛋白激酶组中一组新的丝氨酸/苏氨酸激酶。这种哺乳动物激酶家族包括三名成员,VRK1,VRK2,和VRK3(1-3)。VRK1具有自体磷酸化活性并能够磷酸化几个转录因子,包括p53(4),ATF2(5),和c-Jun(6)。VRK2与内质网相关联(7)。 VRK3能够抑制ERK的活性,通过直接的相互作用和激活MAP激酶磷酸酶VHR(8)。进一步的功能和结构分析将阐明VRK蛋白质在细胞调控中的新作用。 |
存放说明 | -20C |
计算分子量 | 48 |
参考图片Western blot analysis of extracts from 293 and HeLa cells using VRK1 (1F6) Mouse mAb.Western blot方法检测293和Hela细胞提取物,使用的抗体为VRK1 (1F6) Mouse mAb。 |