| 货号 | 2848S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Vav2 (C64H2) Rabbit mAb detects endogenous levels of total Vav2 protein. The antibody is not expected to cross-react with Vav1 or Vav3 based on the sequence of the immunogenic peptide. |
| 使用方法 | WB(1:1000) IP (1:200) |
| 供应商 | CST |
| 背景 | Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regulating actin cytoskeleton organization (reviewed in 1). Phosphorylation stimulates the GEF activity of Vav protein towards Rho/Rac (2,3). |
| 存放说明 | -20C |
| 计算分子量 | 100 |
Western blot analysis of extracts from various cell types using Vav2 (C64H2) Rabbit mAb. 使用Vav2 (C64H2) Rabbit mAb兔单抗，免疫印迹(Western blot)分析不同细胞中Vav2蛋白水平。 |
