USP13 (D4P3M) Rabbit mAb
货号：
12577S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12577S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | USP13 (D4P3M) Rabbit mAb recognizes endogenous levels of total USP13 protein. This antibody does not cross-react with USP5/ISOT. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action (1,2). Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD, and JAMM enzymes. Ubiquitin carboxyl-terminal hydrolase 13 (USP13; isopeptidase T-3) contains four ubiquitin-associated/translation elongation factor EF1B, amino terminal (UBA) domains and one ubiquitin-specific processing protease (UBP) domain. The UBP domain of USP13 contains a catalytic site, a zinc finger domain, and two UBA domains. Similar to other USP family members, USP13 contains cysteines and histidines that are likely involved in its catalytic mechanism. Studies show that USP13 plays a critical role in autophagy through the deubiquitination of target proteins such as BECN1 and USP10 (3). Research also suggests that USP13 is implicated in the pathogenesis of melanoma through its ability to regulate the ubiquitination status of MITF (4). |
| 存放说明 | -20C |
| 计算分子量 | 100 |
参考图片Western blot analysis of extracts from various cell lines using USP13 (D4P3M) Rabbit mAb. Western blot检测多种细胞提取物，采用USP13 (D4P3M) Rabbit mAb。 |
