| 货号 | 93782S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 应用 | WB |
| 目标/特异性 | GPR37L1 (D8F5Q) Rabbit mAb recognizes endogenous levels of total GPR37L1 protein. |
| 使用方法 | Western Blotting (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | GPR37-like receptor (GPR37L1), also known as endothelin B receptor-like protein 2 (ETBR-LP-2) and GPCR/CNS2, is an orphan G protein coupled-receptor (1,2,3). GPR37L1 and its closely related receptor, GPR37, are endothelin receptor-like GPCRs that are highly expressed in the central nervous system. GPR37L1 is broadly expressed in the brain and regulates multiple neuronal functions, including cerebellar development (4). Studies also indicate that GPR37L1 and GPR37 may be receptors for prosaposin and prosaptide. Peptide-dependent modulation of GPR37L1 activity may regulate neuronal and glial survival, as prosaposin is known to exert neuroprotective, neurotrophic, and gliotrophic actions. (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 48 |
| 参考文献 | 1 . Leng, N. et al. (1999) Brain Res Mol Brain Res 69, 73-83. 2 . Zeng, Z. et al. (1997) Biochem Biophys Res Commun 233, 559-67. 3 . Valdenaire, O. et al. (1998) FEBS Lett 424, 193-6. 4 . Marazziti, D. et al. (2013) Proc Natl Acad Sci U S A 110, 16486-91. 5 . Meyer, R.C. et al. (2013) Proc Natl Acad Sci U S A 110, 9529-34. 6 . Misasi, R. et al. (2009) Cent Nerv Syst Agents Med Chem 9, 119-31. |
Western blot analysis of extracts from the indicated tissues using GPR37L1 (D85F8) Rabbit mAb (upper) and α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower). |
