| 货号 | 88300S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Mouse |
| 应用 | WB |
| 目标/特异性 | Integrin β8 (D1V7M) Rabbit mAb recognizes endogenous levels of total integrin β8 protein. |
| 使用方法 | Western Blotting (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Integrin α5β8 facilitates activation and release of TGF-β, which has immunosuppressive effects (1). Deletion of integrin β8 from dendritic cells led to development of inflammatory bowl disease and autoimmunity in mice, as well as failure to induce regulatory T cells that require TGF-β for development (2). TGF-β is also involved in Th17 cell differentiation. Mice lacking expression of integrin β8 on dendritic cells fail to develop Th17 cells and are protected from Th17-mediated autoimmune disease (3). Regulatory T cells express high levels of integrin α5β8, which enables them to suppress pathogenic T cell activation by activating latent TGF-β (4). Integrin β8 is also essential for vascular morphogenesis as integrin β8-deficient mice are embryonic or perinatal lethal and exhibit insufficient and abnormal vascular morphogenesis (5). |
| 存放说明 | -20C |
| 计算分子量 | 98 |
| 参考文献 | 1 . Mu, D. et al. (2002) J Cell Biol 157, 493-507. 2 . Travis, M.A. et al. (2007) Nature 449, 361-5. 3 . Melton, A.C. et al. (2010) J Clin Invest 120, 4436-44. 4 . Worthington, J.J. et al. (2015) Immunity 42, 903-15. 5 . Zhu, J. et al. (2002) Development 129, 2891-903. |
Western blot analysis of extracts from mouse brain, mouse colon, and mouse lung using Integrin β8 (D1V7M) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). |
