| 货号 | 86290S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 应用 | WB |
| 目标/特异性 | MACC1 (D2K7V) Rabbit mAb recognizes endogenous levels of total MACC1 protein. |
| 使用方法 | Western Blotting (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The gene encoding metastasis-associated in colon cancer-1 (MACC1) was identified based on its overexpression in metastatic colon carcinoma (1), and was later shown to be overexpressed in multiple human cancers, including hepatocellular carcinoma, gastric cancer, head and neck cancer, and breast cancer (2-5). MACC1 regulates HGF/MET and β-catenin signaling, resulting in increased proliferation, migration and invasion, and initiation of the epithelial-mesenchymal transition (EMT) (2). Researchers have shown that MACC1 can be used as a prognostic indicator in solid tumors, and that it has potential as a therapeutic target (6). |
| 存放说明 | -20C |
| 计算分子量 | 97 |
| 参考文献 | 1 . Stein, U. et al. (2009) Nat Med 15, 59-67. 2 . Sun, D.W. et al. (2015) Int J Clin Exp Med 8, 4769-77. 3 . Sun, D.W. et al. (2015) Int J Clin Exp Med 8, 4769-77. 4 . Tan, W. et al. (2016) Oncotarget 7, 84408-84415. 5 . Wu, Z. et al. (2015) Biomed Res Int 2015, 252043. 6 . Stein, U. (2013) Expert Opin Ther Targets 17, 1039-52. |
Western blot analysis of extracts from various cell lines using MACC1 (D2K7V) Rabbit mAb (upper) or α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower). |
