| 货号 | 97573S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat |
| 应用 | WB,IP |
| 目标/特异性 | ABHD6 (D3C8N) Rabbit mAb recognizes endogenous levels of total ABHD6 protein. |
| 使用方法 | Western Blotting (1:1000) Immunoprecipitation (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | ABHD6 (α/β-Hydrolase domain-containing 6) is a monoacylglycerol lipase, ubiquitously expressed with the highest expression in brown adipose tissue, small intestine, and brain (1). A high-fat diet upregulates ABHD6 mRNA expression in small intestine and liver, and ABHD6 knockdown protects against high-fat diet-induced obesity, hepatic steatosis, and systemic insulin resistance (2). In addition, it has been shown that ABHD6 is a negative modulator of glucose-stimulated insulin secretion (3). In the central nervous system, ABHD6 is expressed postsynptically and degrades the endocannabinoid 2-arachidonoylglycerol (2-AG), an endogenous activator of cannabinoid receptors (4,5). Inhibitors of α/β-hydrolase domain 6 (ABHD6) have been actively pursued as a promising approach to treat inflammation, metabolic disorders, and epilepsy (2,6,7). |
| 存放说明 | -20C |
| 计算分子量 | 32 |
| 参考文献 | 1 . Lord, C.C. et al. (2013) Biochim Biophys Acta 1831, 792-802. 2 . Thomas, G. et al. (2013) Cell Rep 5, 508-20. 3 . Zhao, S. et al. (2014) Cell Metab 19, 993-1007. 4 . Blankman, J.L. et al. (2007) Chem Biol 14, 1347-56. 5 . Marrs, W.R. et al. (2010) Nat Neurosci 13, 951-7. 6 . Alhouayek, M. et al. (2013) Proc Natl Acad Sci U S A 110, 17558-63. 7 . Naydenov, A.V. et al. (2014) Neuron 83, 361-71. |
Western blot analysis of total extracts from various cell lines using ABHD6 (D3C8N) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). |
