| 货号 | 18572S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat |
| 应用 | WB |
| 目标/特异性 | Syntaxin 1A (D4E2W) Rabbit mAb recognizes endogenous levels of total Syntaxin 1A protein. |
| 使用方法 | Western Blotting (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Syntaxin 1A (STX1A) is a SNARE protein involved in intracellular membrane fusion, including synaptic vesicle fusion (1). At the synapse, syntaxin 1 is located at the presynaptic plasma membrane and is therefore categorized as a t-SNARE protein (2). The amino-terminal domain of syntaxin 1 interacts with Munc18-1 and this interaction is essential for synaptic vesicle fusion (3). Although originally characterized from neural tissues, research studies have demonstrated syntaxin 1A expression in exocrine tissues such as pancreatic islets (4) where it negatively regulates insulin release (5). |
| 存放说明 | -20C |
| 计算分子量 | 33 |
| 参考文献 | 1 . Südhof, T.C. and Rothman, J.E. (2009) Science 323, 474-7. 2 . Fukuda, R. et al. (2000) Nature 407, 198-202. 3 . Zhou, P. et al. (2013) EMBO J 32, 159-71. 4 . Jacobsson, G. et al. (1994) Proc Natl Acad Sci U S A 91, 12487-91. 5 . Nagamatsu, S. et al. (1996) J Biol Chem 271, 1160-5. |
Western blot analysis of extracts from mouse brain, mouse lung, and rat brain using Syntaxin 1A (D4E2W) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). |
