| 货号 | 74748S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat |
| 应用 | WB,IP |
| 目标/特异性 | Kv4.2 (D3E7G) Rabbit mAb recognizes endogenous levels of total Kv4.2 protein. This antibody does not cross-react with Kv4.1 and Kv4.3 proteins. |
| 使用方法 | Western Blotting (1:1000) Immunoprecipitation (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Kv4.2 is a voltage-gated potassium channel that belongs to the Shal-related subfamily. Kv4.2 mediates K+ transport in excitable membranes primarily in the brain, where it regulates neuronal excitability, synaptic plasticity, and the circadian rhythm of locomotor activity (1-6). In rodent heart, Kv4.2 mediates the transient outward current (Ito), which contributes to early repolarization and the cardiac action potential (7). Kv4.2 can form homotetramers or heterotetramers with other members of the Shal-related subfamily. Interaction with modulating β subunits such as KChIP family proteins modulates Kv4.2 expression at cell surface and its channel activity (8-10). |
| 存放说明 | -20C |
| 计算分子量 | 70 |
| 参考文献 | 1 . Serôdio, P. and Rudy, B. (1998) J Neurophysiol 79, 1081-91. 2 . Shibata, R. et al. (2000) J Neurosci 20, 4145-55. 3 . Zhao, C. et al. (2011) Hippocampus 21, 288-97. 4 . Granados-Fuentes, D. et al. (2012) J Neurosci 32, 10045-52. 5 . Labno, A. et al. (2014) PLoS One 9, e84086. 6 . Yao, J.J. et al. (2016) J Biol Chem 291, 17369-81. 7 . Yeola, S.W. and Snyders, D.J. (1997) Cardiovasc Res 33, 540-7. 8 . Kim, L.A. et al. (2004) J Biol Chem 279, 5549-54. 9 . Jerng, H.H. et al. (2004) Biophys J 87, 2380-96. 10 . Kitazawa, M. et al. (2014) J Biol Chem 289, 17597-609. |
Western blot analysis of extracts from human, mouse, and rat brain using Kv4.2 (D3E7G) Rabbit mAb. |
