4EHP (D54C2) Rabbit mAb
货号：
6916S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6916S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | 4EHP (D54C2) Rabbit mAb recognizes endogenous levels of total 4EHP protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Eukaryotic initiation factor 4E (eIF4E) binds to the mRNA cap structure to mediate the initiation of translation (1,2). eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex (2). eIF4B is thought to assist the eIF4F complex in translation initiation. Upon activation by mitogenic and/or stress stimuli mediated by Erk and p38 MAPK, Mnk1 phosphorylates eIF4E at Ser209 in vivo (3,4). Two Erk and p38 MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for Mnk1 kinase activity (3). The carboxy-terminal region of eIF4G also contains serum-stimulated phosphorylation sites, including Ser1108, Ser1148, and Ser1192 (5). Phosphorylation at these sites is blocked by the PI3 kinase inhibitor LY294002 and by the FRAP/mTOR inhibitor rapamycin. |
| 存放说明 | -20C |
| 计算分子量 | 28 |
参考图片Western blot analysis of extracts from 293 and RD cells using 4EHP (D54C2) Rabbit mAb. 使用4EHP (D54C2) Rabbit mAb兔单抗，免疫印迹（Western blot）分析293和RD细胞系提取物。 |
