Acidic FGF (11H11) Rabbit mAb
货号：
3139S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3139S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Acidic FGF (11H11) Rabbit mAb detects recombinant human aFGF proteins at various concentration. This antibody does not cross-react with human bFGF. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Fibroblast growth factors are a family of broad-spectrum growth factors influencing a plethora of cellular activities. The interaction of at least 23 ligands, 4 receptors and multiple coreceptors provides a dramatic complexity to a signaling system capable of effecting a multitude of responses (1,2). Basic fibroblast growth factor (bFGF or FGF2), initially identified as a mitogen with prominent angiogenic properties, is now recognized as a multifunctional growth factor (3). It is clear that bFGF produces its biological effects in target cells by signaling through cell-surface FGF receptors. bFGF binds to all four FGF receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic downstream target proteins, including FRS-2, PLC and Crk (4,5). The FGF signaling pathway appears to play a significant role not only in normal cell growth regulation but also in tumor development and progression (6).
Acidic FGF (aFGF or FGF1) is another extensively investigated protein of the FGF family. aFGF shares 55% DNA sequence homology with bFGF. These two growth factors are ubiquitously expressed and exhibit a wide spectrum of similiar biological activities with quantitative differences likely due to variation in receptor affinity or binding (7). |
| 存放说明 | -20C |
| 计算分子量 | 17 |
参考图片Western blot analysis of recombinant human aFGF at various concentrations, using Acidic FGF (11H11) Rabbit mAb.使用Acidic FGF (11H11) 兔单抗对多种浓度下重组人aFGF进行western blot分析。 |
