| 货号 | 12796S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | <p>The actin-filament associated protein (AFAP) family consists of AFAP1, AFAP1L1, and AFAP1L2/XB130, a group of structurally similar proteins that play distinct roles in the regulation of cytoskeletal dynamics and signal transduction. Actin filament-associated protein 1-like 2 (AFAP1L2, XB130) is an adaptor protein that regulates signaling downstream of multiple kinases, including Src, Akt, and the thyroid specific kinase RET/PTC (1-3). Through these pathways, AFAP1L2/XB130 mediates transcriptional regulation, cell proliferation, motility, and microRNA expression (4,5). Research has shown that AFAP1L2/XB130 is involved in the proliferation and survival of thyroid tumor cells (6), and may have value in gastric cancer prognosis (7).</p>肌动蛋白丝相关蛋白（AFAP）家族包含有AFAP1，AFAP1L1和AFAP1L2/XB130，一组结构相似的蛋白在调控细胞骨架活性和信号转导过程中发挥了不同的作用。Actin filament-associated protein 1-like 2 (AFAP1L2, XB130)是一个调控多种疾病下游信号通路的接头蛋白，包括Src, Akt,和甲状腺特异性kinase RET/PTC（1-3）。通过这些信号通路，AFAP1L2/XB130介导了转录调控，细胞增殖，运动和microRNA表达（4,5）。研究显示AFAP1L2/XB130涉及了甲状腺肿瘤细胞的增殖和存活（6），还可能在胃癌预后过程中发挥作用（7）。 |
| 存放说明 | -20C |
| 计算分子量 | 130 |
Immunoprecipitation of AFAP1L2/XB130 from A-431 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or AFAP1L2/XB130 (D4A5) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot was performed using AFAP1L2/XB130 (D4A5) Rabbit mAb.使用Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) 或AFAP1L2/XB130 (D4A5) Rabbit mAb (lane 3)对A-431细胞的AFAP1L2/XB130进行免疫沉淀实验。Lane 1是10%上样量。使用AFAP1L2/XB130 (D4A5) Rabbit mAb进行western blot分析。 | |
Western Blot analysis of extracts from various cell types using AFAP1L2/XB130 (D4A5) Rabbit mAb.使用AFAP1L2/XB130 (D4A5) Rabbit mAb对多种细胞提取物进行western blot分析。 |
