| 货号 | 4448S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | AFP (D12C1) Rabbit mAb recognizes endogenous levels of total AFP protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 背景 | Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells (1,2). The tumor suppressor gene p53 and β-catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Research studies have shown that elevated serum AFP levels are predictive of hepatocellular carcinoma (3). |
| 存放说明 | -20C |
| 计算分子量 | 65 |
Western blot analysis of extracts from Hep G2 cells using AFP (D12C1) Rabbit mAb. 使用AFP (D12C1) Rabbit mAb兔单抗对Hep G2细胞提取物进行western blot分析。 |
