AID (30F12) Rabbit mAb
货号：
4949S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4949S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | AID (30F12) Rabbit mAb detects endogenous levels of total AID protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Activation-induced cytidine deaminase (AID) is thought to modify RNA due to its high homology to the RNA editing enzyme APOBEC-1. This function, however, has not been confirmed in in vitro studies, which show that AID has significant cytidine deaminase activity, and that this activity is blocked by zinc chelation (1).
The B cell immune system must specifically recognize several infectious agents, which vastly outnumber immunoglobulin gene segments present in a given organism. Mechanisms such as somatic hypermutation, isotype switch recombination and gene conversion introduce diversity and specificity to the immune system. Analysis of mouse models and patients with AID deficiency has established a link between all three of these mechanisms and AID function (2). AID protein is detected in germinal center centroblast and germinal center derived lymphomas (Burkitt lymphoma), but not in pre-germinal center B cells or post-germinal center neoplasms (B cell chronic lymphocytic leukemia and multiple myeloma) (3). |
| 存放说明 | -20C |
| 计算分子量 | 24 |
参考图片Western blot analysis of extracts from various cell types using AID (30F12) Rabbit mAb.Western免疫印迹。用AID (30F12) Rabbit mAb研究各种细胞类型的细胞提取液。 |
