| 货号 | 4959S |
| 反应种属 | Human |
| 来源宿主 | Rat IgG2b |
| 应用 | WB |
| 目标/特异性 | AID (EK2 5G9) Rat mAb detects endogenous levels of total AID protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | Activation-induced cytidine deaminase (AID) is thought to modify RNA due to its high homology to the RNA editing enzyme APOBEC-1. This function, however, has not been confirmed in in vitro studies, which show that AID has significant cytidine deaminase activity, and that this activity is blocked by zinc chelation (1). The B cell immune system must specifically recognize several infectious agents, which vastly outnumber immunoglobulin gene segments present in a given organism. Mechanisms such as somatic hypermutation, isotype switch recombination and gene conversion introduce diversity and specificity to the immune system. Analysis of mouse models and patients with AID deficiency has established a link between all three of these mechanisms and AID function (2). AID protein is detected in germinal center centroblast and germinal center derived lymphomas (Burkitt lymphoma), but not in pre-germinal center B cells or post-germinal center neoplasms (B cell chronic lymphocytic leukemia and multiple myeloma) (3). |
| 存放说明 | -20C |
| 计算分子量 | 24 |
Western blot analysis of total cell lysates from P3HR-1 and Ramos cells using AID (EK2 5G9) Rat mAb.Western免疫印迹。用AID (EK2 5G9) Rat mAb研究P3HR-1 和 Ramos 细胞的细胞提取液。 | |
Immunohistochemical analysis of paraffin-embedded human tonsil using AID (EK2 5G9) Rat mAb.免疫组织化学染色分析石蜡包埋人扁桃体组织。所用抗体为AID (EK2 5G9) Rat mAb。 | |
Immunohistochemical analysis of paraffin-embedded human tonsil using AID (EK2 5G9) Rat mAb. (Image courtesy of Paula Smith and Dr. Riccardo Dalla-Favera, Columbia Univerisity, New York, NY.)免疫组织化学染色分析石蜡包埋人扁桃体组织。所用抗体为AID (EK2 5G9) Rat mAb。(图片来源于Paula Smith 和Dr. Riccardo Dalla-Favera, Columbia Univerisity, New York, NY.) |
