AKAP5 (D28G3) Rabbit mAb
货号：
5671S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5671S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | AKAP5 (D28G3) Rabbit mAb recognizes endogenous levels of total AKAP5 protein. This antibody does not cross-react with other AKAP family proteins. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell (1). Beyond a common amphipathic alpha helix that is responsible for recruiting the PKA regulatory subunit (RIα, RIIα, RIβ, or RIIβ), individual AKAPs contain additional domains responsible for the recrutiment of additional signaling proteins (phosphodiesterases, phosphatases, cytoskeletal components, other kinase, etc.) or restricting AKAP to a specific subcellular location (1). AKAP5 (also known as P75, AKAP75, or AKAP79) is predominantly expressed in neuronal tissues and cells where it serves to localize type II PKA to post-synaptic densities (2-4). AKAP5 specifically binds to the regulatory subunit of PKAIIβ, anchoring the enzyme to the plasma membrane and sites of cytoskeletal/membrane junctions (4-5). The other binding domains of AKAP5 have been shown to interact with calmodulin, PP2B, and calcineurin suggesting that AKAP5 may act to coordinate the cAMP- and Ca2+-sensing pathways in various cell types (5-8). |
| 存放说明 | -20C |
| 计算分子量 | 79 |
参考图片Western blot analysis of extracts from various cell lines using AKAP5 (D28G3) Rabbit mAb. 对多个细胞系使用AKAP5(D28G3)兔单克隆抗体进行Western blot分析。 |
