| 货号 | 3215S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IF-IC |
| 目标/特异性 | AP-2α (C83E10) Rabbit mAb detects endogenous levels of total AP-2α protein. |
| 使用方法 | WB(1:1000) IF-IC (1:100) |
| 供应商 | CST |
| 背景 | The sequence-specific transcription factor activator protein 2α (AP-2α) is required for normal growth and morphogenesis during mammalian development (1,2). Decreased or loss of AP-2α expression has been observed in many different types of human cancers including breast cancer (3,4), ovarian cancer (5), melanoma (6) and prostate cancer (7). These findings suggest that AP-2α expression plays a crucial role in tumorigenicity. Studies have also shown that p53 overexpression in human breast carcinoma cells induces the level of AP-2α expression. Furthermore, p53 binds to the cis-element in the AP-2α promoter, suggesting that AP-2α is a target of p53. AP-2α may mediate the effect of p53 to inhibit cell proliferation (8). |
| 存放说明 | -20C |
| 计算分子量 | 48 |
Western blot analysis of extracts from various cell types using AP-2α (C83E10) Rabbit mAb. Western免疫印迹。用AP-2α (C83E10) Rabbit mAb 兔单抗研究各种细胞类型的细胞提取液。 | |
Confocal immunofluorescent analysis of HeLa cells using AP-2α (C83E10) Rabbit mAb (green). Actin filaments have been labeled with DY-554 phalloidin (red). 共聚焦免疫荧光分析HeLa 细胞，所用抗体为AP-2α (C83E10) Rabbit mAb 兔单抗(绿色)。肌动蛋白微丝用 DY-554 phalloidin (红色)标记。 |
