| 货号 | 2450S |
| 反应种属 | Human/Monkey/Bovine |
| 来源宿主 | Mouse |
| 应用 | W/IHC-P/IF-P |
| 目标/特异性 | APP/beta-Amyloid (NAB228) Mouse mAb detects endogenous levels of APP/beta-Amyloid protein. Although this antibody recognizes both the phospho and non-phospho forms of the protein, it has been shown to prefer the phosphorylated form in some systems. |
| 使用方法 | WB(1:1000) IHC-P (1:50) IF-P (1:50) |
| 供应商 | CST |
| 背景 | Amyloid β (A4) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain (A-β), which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released A-β fragments form the main components of amyloid plaques in Alzheimer disease (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). The phosphorylation at Thr668 (at a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell cycle dependent and peaks during G2/M-phase (4). The APP Thr668 phosphorylated form exists in adult rat brain and correlates with cultured neuronal differentiation (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 100 to 140 |
Immunohistochemical analysis of paraffin-embedded Alzheimers brain, using APP/beta-Amyloid (NAB228) Mouse mAb. | |
免疫组化分析石蜡包埋的阿尔茨海默病大脑，使用的抗体是APP/beta-Amyloid (NAB228) Mouse mAb 鼠单抗。 |
