Atlastin-1 (D2E6) Rabbit mAb
货号：
12728S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12728S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | <p>Atlastin proteins are highly conserved members of the dynamin superfamily of membrane GTPases that are involved in the formation of vesicles for the endocytotic and secretory processes (1). Atlastins are required to establish and maintain the morphology of the tubular endoplasmic reticulum (ER) and are therefore important in ER function (2). GTP hydrolysis and dimerization are required for atlastin-dependent ER membrane fusion (3).</p><p>Atlastin GTPase 1 (ATL1) is primarily expressed in brain, while the related atlastin 2 and atlastin 3 proteins are ubiquitously expressed (4). Mutations in the atlastin 1 gene SPG3A and the ER defects that result are thought to cause one form of hereditary spastic paraplegia (HSP), a group of heterogeneous neurological disorders characterized by severe progressive spasticity of the lower limbs (5,6).</p>Atlastin蛋白是高度保守的膜GTPases dynamin超家族成员，涉及细胞内吞和分泌过程中囊泡的形成（1）。Atlastins对于建立和维持管状内质网（ER）是必须的，因此对于ER发挥作用非常重要（2）。Atlastin依赖的ER膜融合需要GTP水解和二聚化（3）。Atlastin GTPase 1 (ATL1)最初在脑中表达，相关的atlastin2和atlastin3蛋白则广泛表达（4）。atlastin 1基因SPG3A突变以及ER缺陷会导致遗传性痉挛性截肢（HSP），一种异质性的神经系统疾病的特点是双下肢重度痉挛(5,6)。 |
| 存放说明 | -20C |
| 计算分子量 | 55 |
参考图片Western blot analysis of extracts from human, mouse and rat brain using Atlastin-1 (D2E6) Rabbit mAb.使用Atlastin-1 (D2E6) Rabbit mAb对人，小鼠和大鼠脑组织提取物进行western blot分析。 |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human atlastin-1 (hAlastin-1-Myc/DDK; +), atlastin-2 (hAlastin-2-Myc/DDK; +) or atlastin-3 (hAlastin-3-Myc/DDK; +) protein, using Atlastin-1 (D2E6) Rabbit mAb (upper) or Myc-Tag (71D10) Rabbit mAb #2278 (lower).模拟转染（-）或转染了表达Myc/DDK-tagged全长人atlastin-1 (hAlastin-1-Myc/DDK; +)的293T细胞提取物，使用Atlastin-1 (D2E6) Rabbit mAb (上) 或 Myc-Tag (71D10) Rabbit mAb #2278 (下)进行western blot分析。 |
