| 货号 | 13934S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:200) |
| 供应商 | CST |
| 背景 | Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are PI3 kinase-related kinase (PIKK) family members that phosphorylate multiple substrates on serine or threonine residues that are followed by a glutamine in response to DNA damage or replication blocks (1-3). Despite the essential role of ATR in cell cycle signaling and DNA repair processes, little is known about its activation. Phosphorylation of ATR at serine 428 in response to UV-induced DNA damage has been suggested as a means of activating ATR (4,5). Threonine 1989 was also recently identified as a potential marker of activated ATR (6,7). |
| 存放说明 | -20C |
| 计算分子量 | 300 |
Western blot analysis of extracts from various cell lines using ATR (E1S3S) Rabbit mAb. | |
Immunoprecipitation of ATR from HT-29 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or ATR (E1S3S) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot was performed using ATR Antibody #2790. |
