BAFF (D7I1U) Rabbit mAb【科瑞奥博】

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BAFF (D7I1U) Rabbit mAb

货号： 19944S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	19944S
反应种属	Human
来源宿主	Rabbit
应用	W/IP
目标/特异性	BAFF (D7I1U) Rabbit mAb recognizes endogenous levels of total BAFF protein.
使用方法	WB(1:1000) IP (1:100)

性能
供应商	CST
背景	BAFF, a member of the TNF superfamily of proteins, is a homotrimeric transmembrane protein, which is cleaved to produce a soluble cytokine (1). BAFF may also further oligomerize into 60-mer structures (1). BAFF is expressed by monocytes, neutrophils, macrophages, dendritic cells, activated T cells, and epithelial cells (1,2). BAFF plays a key role in B cell development, survival, and activation (1,3,4). BAFF binds to three distinct receptors, BAFF-R, TACI, and BCMA (1). These receptors are differentially expressed during B cell development and among B cell subsets (1,2,4). While BAFF-R and BCMA bind to the homotrimeric form of BAFF, TACI only binds to membrane bound or higher order BAFF structures (1). The BAFF/ BAFF-R interaction activates both canonical and non-canonical NF-κB pathways, PI3K/Akt, and mTOR (2,4). Activation of the noncanonical NF-κB pathway via BAFF-R is negatively regulated by TRAF3 (5). Research studies have shown that elevated levels of BAFF may exacerbate many autoimmune disorders, making it a potential therapeutic target (2).
存放说明	-20C
计算分子量	17,29,31

参考图片

Immunoprecipitation of BAFF from U-937 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or BAFF (D7I1U) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using BAFF (D7I1U) Rabbit mAb.对U-937细胞的细胞提取物中的BAFF进行免疫共沉淀，使用抗体是 Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (泳道2)或 BAFF (D7I1U) Rabbit mAb (泳道3). 泳道1为10%的加入量。Western blot分析使用的抗体是BAFF (D7I1U) Rabbit mAb。

Western blot analysis of extracts from U-937 cells using BAFF (D7I1U) Rabbit mAb.Western blot分析U-937细胞的细胞提取物，使用抗体是BAFF (D7I1U) Rabbit mAb。

Western blot analysis of 1 ng recombinant Human BAFF/TNFSF13B (hBAFF) #5233 using BAFF (D7I1U) Rabbit mAb.Western blot分析1 ng recombinant Human BAFF/TNFSF13B (hBAFF) #5233 ，使用抗体是BAFF (D7I1U) Rabbit mAb。