| 货号 | 6947S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P |
| 目标/特异性 | Bak (D2D3) Rabbit mAb recognizes endogenous levels of total Bak protein. |
| 使用方法 | WB(1:1000) IP (1:100) IHC-P (1:800) |
| 供应商 | CST |
| 背景 | Bak is a proapoptotic member of the Bcl-2 family (1). This protein is located on the outer membrane of mitochondria and is an essential component for transduction of apoptotic signals through the mitochondrial pathway (2,3). Upon apoptotic stimulation, an upstream stimulator like truncated BID (tBID) induces conformational changes in Bak to form oligomer channels in the mitochondrial membrane for cytochrome c release. The release of cytochrome c to the cytosol activates the caspase-9 pathway and eventually leads to cell death (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 25 |
Western blot analysis of extracts from various cell lines using Bak (D2D3) Rabbit mAb. Western免疫印迹。用Bak (D2D3) Rabbit mAb 兔单抗研究各种细胞系的细胞提取液。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Bak (D2D3) Rabbit mAb. 免疫组织化学染色分析石蜡包埋人肺癌组织。所用抗体为Bak (D2D3) Rabbit mAb 兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using Bak (D2D3) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). 免疫组织化学染色分析石蜡包埋人结肠癌组织，在对照多肽(左图)和抗原特异性多肽(右图)处理，所用抗体为Bak (D2D3) Rabbit mAb 兔单抗。 |
