| 货号 | 14796S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P |
| 使用方法 | WB(1:1000) IP (1:50) IHC-P (1:400) |
| 供应商 | CST |
| 背景 | Bax is a key component for cellular induced apoptosis through mitochondrial stress (1). Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane (2). Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membranes permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis (3,4). |
| 存放说明 | -20C |
| 计算分子量 | 20 |
Western blot analysis of extracts from various cell lines using Bax (D3R2M) Rabbit mAb (Rodent Preferred). | |
Western blot analysis of extracts from Bax WT MEF and Bax -/- MEF cells using Bax (D3R2M) Rabbit mAb (Rodent Preferred) (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). MEF cells are courtesy of Dr. Junying Yuan, of Harvard Medical School, Boston, MA. | |
Immunohistochemical analysis of paraffin-embedded Bax WT MEF (left) and Bax -/- MEF (right) cell pellets using Bax (D3R2M) Rabbit mAb (Rodent Preferred). MEF cells are courtesy of Dr. Junying Yuan, of Harvard Medical School, Boston, MA. | |
Immunohistochemical analysis of paraffin-embedded rat spleen using Bax (D3R2M) Rabbit mAb (Rodent Preferred). | |
Immunohistochemical analysis of paraffin-embedded mouse kidney using Bax (D3R2M) Rabbit mAb (Rodent Preferred). | |
Immunohistochemical analysis of paraffin-embedded mouse lung using Bax (D3R2M) Rabbit mAb (Rodent Preferred). |
