Bcl10 (C78F1) Rabbit mAb
货号：
4237S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4237S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Bcl10 (C78F1) Rabbit mAb detects endogenous levels of total Bcl10 protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Bcl10/CIPER/CLAP/mE10 is a widely expressed CARD (caspase recruitment domain) containing protein shown to induce apoptosis and activate NF-κB (1-5). The CARD domain mediates self-oligomerization, interactions with other CARD proteins and is necessary for NF-κB activation, although the precise mechanism which Bcl10 regulates these processes is not fully understood. The discovery of Bcl10 came from observations of the chromosomal translocation t(1;14)(p22;q32) from B cell lymphomas of the mucosa-associated lymphoid tissue (MALT) (1,5). This translocation results in deregulated expression of a truncated form of Bcl10 which lacks apoptotic activity and enhances transformation. Studies from Bcl10 deficient mice demonstrate that Bcl10 is essential for the activation of NF-κB by T- and B-cell receptors (6). One third of Bcl10 deficient mice developed lethal exencephaly. Surviving mice were unaffected by various apoptotic stimuli, but were severely immunodeficient and defective in antigen receptor-induced NF-κB activiation. PKC or T-cell receptor signaling results in a downregulation of Bcl10 protein levels, attenuating both NF-κB activation and cellular proliferation and also provides a negative feedback regulation of the NF-κB signaling to T cell signaling (7). |
| 存放说明 | -20C |
| 计算分子量 | 28 |
参考图片Western blot analysis of extracts from Raji (human), A20 (mouse), and KNRK (rat) cell lines using Bcl10 (C78F1) Rabbit mAb.Western免疫印迹。用Bcl10 (C78F1) Rabbit mAb研究Raji (人源), A20 (小鼠)和KNRK (大鼠)细胞系的细胞提取液。 |
