Bid (3C5) Mouse mAb
货号：
8762S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8762S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 目标/特异性 | Bid (3C5) Mouse mAb recognizes endogenous levels of total Bid protein. This antibody does not cross-react with endogenous levels of tBid during apoptosis. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Bid is a pro-apoptotic “BH3 domain-only” member of the Bcl-2 family originally discovered to interact with both the anti-apoptotic family member Bcl-2 and the pro-apoptotic protein Bax (1). Bid is normally localized in the cytosolic fraction of cells as an inactive precursor and is cleaved at Asp60 by caspase-8 during Fas signaling, leading to translocation of the carboxyl terminal p15 fragment (tBid) to the mitochondrial outer membrane (2-4). Translocation of Bid is associated with release of cytochrome c from the mitochondria, leading to complex formation with Apaf-1 and caspase-9 and resulting in caspase-9 activation (5-7). Thus, Bid relays an apoptotic signal from the cell surface to the mitochondria triggering caspase activation (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 22 |
