BIRC6 (D8B5) Rabbit mAb
货号：
8756S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8756S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | BIRC6 (D8B5) Rabbit mAb recognizes endogenous levels of total BIRC6 protein. Several bands of unknown origin between 120 and 500 kDa are detected in some cell lines. It is possible that these bands are degradation products of BIRC6. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | BIRC6/BRUCE/APOLLON is a member of the inhibitor of apoptosis protein (IAP) family. BIRC6 is a huge 530 kDa membrane-associated protein with a single survivin-like baculoviral IAP repeat (BIR) domain at the amino terminus, and a ubiquitin-conjugating enzyme domain at the carboxy terminus (1-3). Several research studies support the notion that BIRC6 functions as a dual regulator of cell death and cell division (4-6), and BIRC6 is the only essential BIR-containing protein in mammalian cell growth and development (4,7). Research studies have documented the overexpression of BIRC6 in colon cancer stem cells and in other cancer cell lines (8,9). BIRC6 inhibits apoptosis by either 1) binding to and inhibiting caspases (10) or 2) ubiquitinating the IAP antagonist SMAC and the apoptosis initiator caspase 9, thereby targeting these proteins for proteasomal degradation (4,5). BIRC6 itself is regulated by ubiquitination and proteasomal degradation upon stimulation of apoptosis (7,11). |
| 存放说明 | -20C |
| 计算分子量 | 530 |
参考图片Western blot analysis of extracts from various cell lines using BIRC6 (D8B5) Rabbit mAb. Western免疫印迹。用 BIRC6 (D8B5) Rabbit mAb 兔单抗研究各种细胞系的细胞提取液。 |
