BLNK (D8R3G) Rabbit mAb
货号：
12168S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12168S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | BLNK (D8R3G) Rabbit mAb recognizes endogenous levels of total BLNK protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | B cell linker protein (BLNK), also known as SLP-65 or BASH, is an adaptor molecule that plays key roles in B cell activation and B cell antigen receptor (BCR) engagement. BLNK acts at the interface between BCR-associated Syk and downstream signaling cascades (1,2). BLNK has multiple SH2 binding motifs (YXXP) at its amino terminus and an SH2 domain at its carboxy terminus. After BCR ligation, BLNK is phosphorylated by Syk at multiple YXXP motifs including Tyr72, Tyr84, Tyr96, and Tyr178 (1). These phosphorylated motifs provide docking sites for signaling molecules, such as Btk, PLCγ, and Vav. These signaling molecules bind to BLNK through their SH2 domains and together activate downstream signaling pathways (3,4). Through its SH2 domain, BLNK can also interact with tyrosine-phosphorylated targets, such as HPK1, thereby recruiting them to the BCR complex for signaling (5). |
| 存放说明 | -20C |
| 计算分子量 | 68, 70 |
参考图片Western blot analysis of extracts from various cell lines using BLNK (D8R3G) Rabbit mAb. B cell specificity of this antibody is demonstrated by the absence of signal in Jurkat cells.Western blot分析多种细胞系的细胞提取物，使用抗体是BLNK (D8R3G) Rabbit mAb。这种抗体的B细胞特异性主要通过Jurkat细胞信号的显示来证明。 |
