| 货号 | 15125S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:800) |
| 供应商 | CST |
| 背景 | Bromodomain-containing protein 7 (BRD7, BP75, CELTIX-1) is a conserved bromodomain-containing protein that was first identified in a screen for proteins that interact with the PDZ domain of PSD95 (1). Subsequent studies identified BRD7 as a major component of SWI/SNF chromatin remodeling complexes, where it was shown to interact directly with acetylated histones to regulate gene transcription (2,3). BRD7 also interacts with p53, and was shown to participate directly in p53-dependent transcriptional regulation (4). Loss-of-function BRD7 mutations were identified in a subset of wild-type p53 breast cancer tumor samples, implicating BRD7 as a putative tumor-suppressor of potential clinical significance (5). BRD7 also associates with the BRCA1 protein, an interaction that facilitates recruitment of BRCA1 to the ERα gene promoter (6). |
| 存放说明 | -20C |
| 计算分子量 | 85 |
Immunohistochemical analysis of paraffin-embedded MDA-MB-231 (left) and SW620 (right) cell pellets using BRD7 (D9K2T) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using BRD7 (D9K2T) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using BRD7 (D9K2T) Rabbit mAb. | |
Western blot analysis of extracts from various cell lines using BRD7 (D9K2T) Rabbit mAb. |
