| 货号 | 12660S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | CABIN1 (D2B9F) Rabbit mAb recognizes endogenous levels of total CABIN1 protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 背景 | Calcineurin binding protein CABIN1 was originally identified as an inhibitor of the calcium-dependent serine/threonine phosphatase, calcineurin. CABIN1 inhibits calcineurin signaling in T cells, regulating T cell receptor (TCR) signaling, transcription, and apoptosis (1-4). CABIN1 represses myocyte enhancer factor 2 (MEF2)-mediated transcription by recruiting chromatin remodeling enzymes (5), and also negatively regulates the activity of the tumor suppressor p53 (6). In response to genotoxic stress, CABIN1 is degraded and releases its inhibition of p53, allowing p53 to elicit cellular stress responses (7). CABIN1 is also involved in regulation of chromatin structure as part of the highly conserved HIRA/UBN1/CABIN1/ASF1A (HUCA) histone chaperone complex (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 230 |
Immunoprecipitation of CABIN1 from HCT 116 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or CABIN1 (D2B9F) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using CABIN1 (D2B9F) Rabbit mAb.采用免疫共沉淀检测HCT 116细胞提取物的CABIN1, 使用抗体Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane2)或者CABIN1 (D2B9F) Rabbit mAb (lane 3). Lane 1是10% input。Western blot分析使用CABIN1 (D2B9F) Rabbit mAb。 | |
Western blot analysis of extracts from various cell lines using CABIN1 (D2B9F) Rabbit mAb.Western blot检测各种细胞系提取物,使用抗体CABIN1 (D2B9F) Rabbit mAb。 |
