Caspase-11 (17D9) Rat mAb
货号：
14340S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 14340S |
| 反应种属 | Mouse |
| 来源宿主 | Rat IgG2a |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:100) |
性能| 供应商 | CST |
| 背景 | Caspases are a family of aspartate-specific cysteine-dependent proteases that play a critical role in apoptosis as well as inflammatory responses. Pro-inflammatory caspases include caspase-1 and mouse caspase-11 (1). Caspase-11 has about 60% and 55% identity to human caspases-4 and -5, respectively. Caspase-1 cleaves inflammatory cytokines such as pro-IL-1β and IL-18 into their mature forms (2). It is activated by proteolytic cleavage producing a tetramer of its two active subunits, p20 and p10. Canonical activation of caspase-1 occurs through several complex molecular platforms designated “inflammasomes” that include Pycard/Asc, nucleotide-binding oligomerization receptors (NLRs), and AIM2 (3, 4). Non-canonical activation of caspase-1 is triggered by caspase-11, which is transcriptionally induced by toll-like receptor ligands including LPS. Activation of this pathway induces inflammatory cytokines as well as pyroptosis, a form of programmed cell death (5-9). Pyroptosis may be specific for caspase-11, rather than caspase-1, suggesting a unique mechanism for protease. |
| 存放说明 | -20C |
| 计算分子量 | 38, 43 |
参考图片Western blot analysis of extracts from Raw 264.7 or J774.1 cells, untreated (-) or treated with LPS (1 μg/ml, overnight; +) using Caspase-11 (17D9) Rat mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). |
