CD44 (156-3C11) Mouse mAb【科瑞奥博】

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CD44 (156-3C11) Mouse mAb

货号： 3570S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	3570S
反应种属	Human
来源宿主	Mouse
应用	W/IP/IHC-P/IF-IC/F
目标/特异性	CD44 (156-3C11) Mouse mAb detects endogenous levels of total CD44 protein.
使用方法	WB(1:1000) IP (1:50) IHC-P (1:50) F (1:100) IF-IC (1:400)

性能
供应商	CST
背景	CD44 is a type I transmembrane glycoprotein that mediates cell-cell and cell-matrix interaction through its affinity for hyaluronic acid (HA) and possibly through other parts of the extracellular matrix (ECM). CD44 is highly polymorphic, possesses a number of alternative splice variants and undergoes extensive post-translational modifications (1,2). Increased surface levels of CD44 are characteristic of T cell activation, and expression of the protein is upregulated during the inflammatory response. Interactions between CD44 and HER2 have been linked to an increase in ovarian carcinoma cell growth (1-3). CD44 interacts with ezrin, radixin and moesin (ERM), linking the actin cytoskeleton to the plasma membrane and the ECM (4-6). CD44 is constitutively phosphorylated at Ser325 in resting cells. Activation of PKC results in phosphorylation of Ser291, dephosphorylation of Ser325, disassociation of ezrin from CD44, and directional motility (4).
存放说明	-20C
计算分子量	80

参考图片

Immunohistochemical analysis of human tonsil using CD44 (156-3C11) Mouse mAb.免疫组织化学染色分析石蜡包埋人扁桃体组织。所用抗体为CD44 (156-3C11) Mouse mAb。

Immunohistochemical analysis of human Non-Hodgkins lymphoma using CD44 (156-3C11) Mouse mAb.免疫组织化学染色分析石蜡包埋人非霍奇金淋巴瘤。所用抗体为CD44 (156-3C11) Mouse mAb。

Confocal immunofluorescent analysis of Hela cells using CD44 (156-3C11) Mouse mAb (green). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).共聚焦免疫荧光分析Hela细胞，所用抗体为CD44 (156-3C11) Mouse mAb(绿色)。肌动蛋白微丝用Alexa Fluor® 555 phalloidin 标记(红色)。Blue pseudocolor = DRAQ5® #4084 (DNA 荧光染料)。

Flow cytometric analysis of whole blood using CD44 (156-3C11) Mouse mAb.流式细胞仪分析全血，所用抗体为CD44 (156-3C11) Mouse mAb。

Flow cytometric analysis of Hela cells using CD44 (156-3C11) Mouse mAb (blue) compared to a nonspecific negative control antibody (red).流式细胞仪分析Hela，所用抗体为CD44 (156-3C11) Mouse mAb(蓝色) 与非特异性的阴性对照抗体对比 (红色)。

Western blot analysis of extracts from HeLa and PANC1 cell lines using CD44 (156-3C11) Mouse mAb.Western免疫印迹。用CD44 (156-3C11) Mouse mAb研究HeLa 和 PANC1 细胞系的细胞提取液。