CDC37 (D28H7) Rabbit mAb
货号：
4222S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4222S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CDC37 is an important component of the HSP90 chaperone complex (1,2). It was initially identified for its involvement in cell-cycle progression and was later found to have a much broader role as a chaperone for a wide variety of kinases and other proteins (1-3). CDC37 protein has an amino-terminal kinase binding domain followed by a central HSP90 binding domain. It recruits and stabilizes kinases in the HSP90 complex by protecting the newly synthesized kinase peptide chain from degradation and promoting the next step of protein maturation (4,5). CDC37 also suppresses the ATPase activity of HSP90, thereby leading to conformational changes in the complex that preclude target kinase loading (6). CDC37 has been proposed as a therapeutic target because of its important role in multiple kinase pathways involved in proliferation and cancer cell survival, including Raf, Akt, Src, and ErbB2 pathways (7,8).CDC37蛋白是一个HSP90伴侣复合物的重要组成成员(1,2)。该蛋白起初被证明涉及细胞周期进程，之后被发现有个广泛的作用，其作为一个很多激酶和其它蛋白质的分子伴侣 (1-3)。CDC37蛋白有一个氨基末端激酶结合区域，紧接着一个中央HSP90结合区域。通过保护新合成激酶多肽链避免降解和促进蛋白质成熟的接下来步骤进行，该蛋白在HSP90 复合物中招募和稳定激酶(4,5)。CDC37也抑制HSP90蛋白的活性，因此导致在复合物中构象改变，这将阻止靶激酶结合(6)。CDC37蛋白已被建议作为治疗靶点，因为在多种激酶通路涉及到增殖和癌细胞存活包括Raf、Akt、Src和ErbB2通路中起着重要作用(7,8)。 |
| 存放说明 | -20C |
| 计算分子量 | 50 |
参考图片Western blot analysis of extracts from 293, C6 and COS cells using CDC37 (D28H7) Rabbit mAb.使用CDC37 (D28H7) Rabbit mAb，免疫印迹（Western Blot）分析293、C6和COS细胞系CDC37 (D28H7)蛋白水平。 |
