| 货号 | 8944S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IF-IC |
| 目标/特异性 | CEND1 (D6A6) Rabbit mAb recognizes endogenous levels of total CEND1 protein. |
| 使用方法 | WB(1:1000) IP (1:100) IF-IC (1:400) |
| 供应商 | CST |
| 背景 | The progression of progenitor cells towards neuronal differentiation is regulated by cell cycle control and the transition from proliferative to neurogenic cell divisions. Cell cycle exit and neuronal differentiation 1 (CEND1) is a neuronal protein widely expressed in the adult nervous system (1). It is implicated in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system, and its expression marks the exit of proliferative cells from the cell cycle (2,3). Levels of CEND1 expression in the subventricular zone of the adult nervous system are critical for cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis (4). It has recently been shown that neural progenitor cells (NPCs) that overexpress CEND1 display increased neuronal differentiation in a mouse model of brain injury, suggesting its potential use as a therapeutic intervention for neurodegenerative diseases and brain injury (5). |
| 存放说明 | -20C |
| 计算分子量 | 22 |
Confocal immunofluorescent analysis of P14 rat brain using CEND1 (D6A6) Rabbit mAb (green) and Nestin (Rat-401) Mouse mAb #4760 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). 共聚焦免疫荧光分析P14大鼠大脑，使用的抗体是CEND1 (D6A6) Rabbit mAb兔单抗（绿色）和Nestin (Rat-401) Mouse mAb鼠单抗 #4760 （红色）。蓝色伪彩=DRAQ5®＃4084（荧光DNA染料）。 | |
Western blot analysis of extracts from human and rat brain using CEND1 (D6A6) Rabbit mAb. Western blot检测人和大鼠大脑提取物，使用的抗体是CEND1 (D6A6) Rabbit mAb兔单抗。 |
