Chronophin/PDXP (C85E3) Rabbit mAb
货号：
4686S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4686S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Cofilin is a conserved actin-severing protein required for processes that rely on actin dynamics, including cytokinesis and cell motility (reviewed in 1). Regulation of actin dynamics requires the controlled cycling between the phosphorylated and unphosphorylated forms of cofilin (2). The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at the conserved amino-terminal Ser3 of cofilin (3,4). Slingshot (SSH) phosphatase, for which there have been three mammalian isoforms identified, dephosphorylates cofilin in vivo (5). Chronophin (CIN, PDXP) is a haloacid dehalogenase phosphatase that also dephosphorylates cofilin. Alteration of CIN activity through overexpression of either the wildtype or phosphatase-inactive mutant CIN interferes with actin dynamics, cell morphology and cytokinesis (6).Cofilin蛋白是一个保守的剪切类肌动蛋白结合蛋白（actin-severing protein），对于依赖actin动力的生理过程需要Cofilin蛋白，包括胞质分裂和细胞迁移（1）。actin动力的调节需要在cofilin蛋白的磷酸化形式和非磷酸化形式之间控制循环 (2)。通过 LIMK或TESK激酶使cofilin蛋白保守的氨基末端 Ser3位点磷酸化，cofilin蛋白剪切活性被抑制(3,4)。Slingshot (SSH)磷脂酶有三个哺乳类亚型被鉴定，其在体内可以使cofilin蛋白去磷酸化(5)。Chronophin (CIN, PDXP)是一个haloacid dehalogenase磷酸酶，其也可使cofilin蛋白去磷酸化。通过野生型或磷酸酶失活的突变CIN蛋白的过表达，CIN活性的改变干扰actin动力、细胞形态和细胞分裂 (6)。 |
| 存放说明 | -20C |
| 计算分子量 | 31 |
参考图片Western blot analysis of extracts from various cell types using Chronophin/PDXP (C85E3) Rabbit mAb.使用Chronophin/PDXP (C85E3) Rabbit mAb，免疫印迹（Western Blot）分析不同细胞系中Chronophin/PDXP (C85E3)蛋白水平。 |
