| 货号 | 12319S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | c-Myb (D2R4Y) Rabbit mAb recognizes endogenous levels of total c-Myb protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 背景 | c-Myb is a transcriptional activator that specifically recognizes the sequence 5-YAAC[GT]G-3. It is expressed in hematopoietic progenitor cells where it plays an important role in the control of proliferation and differentiation (1-3). c-Myb is required for transcription of genes involved in self-renewal of intestinal stem cells. Importantly, c-Myb regulates expression of Lgr5, a protein expressed in putative intestinal stem cells that give rise to all cell lineages of small intestinal crypts (4). c-Myb is reported to be expressed in colon crypt cells and in human colorectal cancer lines (5,6). Research has shown that c-Myb gene translocations and copy number alterations are found in several leukemias, breast cancer, and other solid tumors (7,8). |
| 存放说明 | -20C |
| 计算分子量 | 80 |
Western blot analysis of extracts from Jurkat and MOLT-4 cells using c-Myb (D2R4Y) Rabbit mAb. 使用c-Myb (D2R4Y)Rabbit mAb兔单抗对Jurkat和MOLT-4细胞提取物进行western blot分析。 |
