COUP-TFI (D4H2) Rabbit mAb
货号：
6364S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6364S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:100) |
性能| 供应商 | CST |
| 背景 | Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family (1). COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes (1-3). COUP-TFI and II bind to 5-AGGTCA-3 motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression (4,5). COUP-TFI is involved in neuronal development, tissue patterning, and differentiation (6-8). COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment (9-12).鸡卵清蛋白上游启动子转录因子（COUP-TF）属于核激素受体家族的NR2亚科（1）。 COUP-TFI和COUP-TFII是两个良好的特征性NR2亚家族成员。这两个成员在其两个锌指DNA结合域和配体结合域（LBD）是高度保守的，可作为下游靶基因的阻遏物或激活剂的功能，来调节不同的生物过程（1-3）。COUP-TFI和II直接或间接地结合5-AGGTCA-3模体回文，通过与其他蛋白质（如RXR）形成异源二聚体来调节下游靶基因的表达（4,5）。COUP-TFI参与神经元的发育、组织发生和分化（6-8）。 已证明COUP-TFII参与血管生成、葡萄糖稳态和间充质细胞的定型（9-12）。 |
| 存放说明 | -20C |
| 计算分子量 | 47 |
参考图片Western blot analysis of extracts from various cell lines using COUP-TFI (D4H2) Rabbit mAb.Western blot方法检测多个细胞系提取物，使用的抗体为COUP-TFI (D4H2) Rabbit mAb. |
