| 货号 | 8684S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P/IF-IC |
| 目标/特异性 | CtBP1 (D2D6) Rabbit mAb recognizes endogenous levels of total CtBP1 protein. |
| 使用方法 | WB(1:1000) IP (1:100) IHC-P (1:100) IF-IC (1:200) |
| 供应商 | CST |
| 背景 | CtBP1 (C-terminal binding protein 1) was first recognized as a cellular factor that interacts with the C-terminal portion of adenovirus E1A, a protein involved in the transcriptional regulation of key cellular genes (1). CtBP1 is able to regulate gene activity through its intrinsic dehydrogenase activity (2,3) and by interacting with Polycomb Group (PcG) proteins during development (4). Along with its homologue, CtBP2, it acts as a transcriptional corepressor of zinc-finger homeodomain factor deltaEF1 to regulate a wide range of cellular processes through transrepression mechanisms (5). Through its direct interaction with PRDM16, CtBP1 has been shown to be involved in brown adipose tissue differentiation by mediating the repression of white fat genes and directing differentiation toward the brown fat gene program (6). CtBP1 also plays a role in lipid metabolic pathways and membrane fission by regulating the fission machinery operating Golgi tubular networks (7). CtBP1 has recently been shown to repress transcription of BRCA1 via a redox regulated mechanism (8). Furthermore, it is thought that downregulation of BRCA1 and E-cadherin in invasive ductal breast carcinoma correlates directly with activation of CtBP1 (9). |
| 存放说明 | -20C |
| 计算分子量 | 47 |
Confocal immunofluorescent analysis of 293T cells using CtBP1 (D2D6) Rabbit mAb (green). Actin filaments were labeled with DY-554 phalloidin (red).使用 CtBP1 (D2D6) 兔单抗对293T细胞进行激光共聚焦荧光分析。使用DY-554鬼笔环肽（红色）标记肌动蛋白丝。 | |
Western blot analysis of extracts from various cell lines using CtBP1 (D2D6) Rabbit mAb.使用CtBP1 (D2D6) 兔单抗对多种细胞提取物进行western blot分析。 | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using CtBP1 (D2D6) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right).在对照肽（左）或抗原特异性肽（右）存在的条件下，使用CtBP1 (D2D6)兔单抗对石蜡包埋的人结肠癌组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma using CtBP1 (D2D6) Rabbit mAb.使用CtBP1 (D2D6) 兔单抗对石蜡包埋的人肺鳞状上皮细胞癌进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using CtBP1 (D2D6) Rabbit mAb.使用CtBP1 (D2D6)兔单抗对石蜡包埋的人前列腺癌组织进行免疫组化分析。 |
