| 货号 | 8049S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | DcR2 (D13H4) Rabbit mAb recognizes endogenous levels of total DcR2 protein. This antibody may detect an unidentified protein of 30 kDa in some cell lines. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 背景 | The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems (1,2). The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling can be controlled by a family of decoy receptors (DcR1, DcR2, and DcR3) that lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand binding (3-5). Expression of decoy receptors can contribute to chemosensitivity and may provide a mechanism for regulation of apoptosis in certain types of cancer (6-8). |
| 存放说明 | -20C |
| 计算分子量 | 45-60 |
Western blot anlaysis of extracts from various cell lines using DcR2 (D13H4) Rabbit mAb. Western blot 检测多种细胞系提取物，使用抗体为DcR2 (D13H4) Rabbit mAb 兔单抗。 | |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct encoding full-length human DcR2 (hDcR2; +), using DcR2 (D13H4) Rabbit mAb. Western blot 检测293T细胞提取物，空质粒(-)或编码全长人DcR2 (hDcR2; +)转染，使用抗体为DcR2 (D13H4) Rabbit mAb 兔单抗。 |
