DPYD (D35A8) Rabbit mAb
货号：
4654S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4654S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | DPYD (D35A8) Rabbit mAb detects endogenous levels of total DPYD protein. The antibody also detects a 50-60 kDa band of unknown origin by western blot. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Dihydropyrimidine dehydrogenase (DPD, DPYD) catalyzes the initial and rate-limiting step in uracil and thymidine catabolism as well as catabolism of the chemotherapeutic drug 5-fluorouracil (5-FU) and its derivatives. DPYD deficiency, which results from mutations in the DPYD gene, causes errors in pyrimidine metabolism and potentially life-threatening side effects in cancer patients treated with 5-FU (reviewed in 1). As a result, ongoing work examines whether or how DPYD gene variation and protein expression can be used to predict 5-FU toxicity (1,2). Several genes that impart resistance to 5-FU were recently identified in human hepatocellular carcinoma (HCC). AEG-1, which is highly expressed in HCC, increases the expression of DPYD. DPYD is expressed more highly in HCC than in normal liver, and this is thought to be one mechanism of 5-FU resistance (3,4). |
| 存放说明 | -20C |
| 计算分子量 | 110 |
参考图片Western blot analysis of extracts from HeLa and IGROV-1 cells using DPYD (D35A8) Rabbit mAb. Wetern blot检测HeLa and IGROV-1细胞系提取物，所用抗体为DPYD (D35A8) Rabbit mAb兔单抗.。 |
