| 货号 | 5430S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Emerin (D9B3) Rabbit mAb detects endogenous level of total Emerin protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Emerin is a broadly expressed integral protein of the nuclear inner membrane (1). It contains a LEM domain and binds to several nuclear proteins, such as BAF (barrier-to-autointegration factor) and A- and B-type lamins, which are important in nuclear functions (2-5). Emerin may regulate gene expression through binding to other transcriptional regulators (6,7). Emerin binds to β-catenin and inhibits its nuclear accumulation (8). Recent studies demonstrate that Emerin is required for HIV-1 infectivity (9). Mutations in Emerin are a major cause of Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive skeletal muscle weakening (10). |
| 存放说明 | -20C |
| 计算分子量 | 30 |
Western blot analysis of extracts from HeLa, 293, and MCF7 cell lines using Emerin (D9B3) Rabbit mAb. 使用Emerin (D9B3) Rabbit mAb，免疫印迹（Western Blot）分析HeLa、293和MCF7细胞中Emerin蛋白水平。 |
