| 货号 | 14606S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:400) |
| 供应商 | CST |
| 背景 | Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6). |
| 存放说明 | -20C |
| 计算分子量 | 95 |
Immunohistochemical analysis of paraffin-embedded HUVEC (left) and HeLa (right) cell pellets using Endoglin (3A9) Mouse mAb. | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using Endoglin (3A9) Mouse mAb. | |
Western blot analysis of extracts from HUVEC cells (+) and A172 cells (-) using Endoglin (3A9) Mouse mAb (upper) or β-Actin (#8457) (lower) as a loading control. | |
Immunohistochemical analysis of paraffin-embedded human ovarian serous carcinoma using Endoglin (3A9) Mouse mAb. | |
Immunohistochemical analysis of paraffin-embedded human breast ductal carcinoma in situ using Endoglin (3A9) Mouse mAb. |
